Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/β-catenin signaling pathway in HCT116 cells

Title
Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/β-catenin signaling pathway in HCT116 cells
Authors
강경수이경미유지혜이희주김철영노주원
Keywords
Wnt/b-catenin; Cancer chemoprevention; Dibenzocyclooctadiene lignan; Schisandra chinensis; Gomisin; Cyclin D1
Issue Date
2012-11
Publisher
Biochemical and biophysical research communications
Citation
VOL 428, NO 2, 285-291
Abstract
Here, we report that gomisin J and gomisin N, dibenzocyclooctadiene type lignans isolated from Schisandra chinensis, inhibit Wnt/β-catenin signaling in HCT116 cells. Gomisins J and N appear to inhibit Wnt/β-catenin signaling by disrupting the interaction between β-catenin and its specific target DNA sequences (TCF binding elements, TBE) rather than by altering the expression of the β-catenin protein. Gomisins J and N inhibit HCT116 cell proliferation by arresting the cell cycle at the G0/G1 phase. The G0/G1 phase arrest induced by gomisins J and N appears to be caused by a decrease in the expression of Cyclin D1, a representative target gene of the Wnt/β-catenin signaling pathway, as well as Cdk2, Cdk4, and E2F-1. Therefore, gomisins J and N, the novel Wnt/β-catenin inhibitors discovered in this study, may serve as potential agents for the prevention and treatment of human colorectal cancers.
URI
http://pubs.kist.re.kr/handle/201004/44037
ISSN
0006291X
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KIST Publication > Article
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