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dc.contributor.author아잠-
dc.contributor.author표정인-
dc.contributor.author김관수-
dc.contributor.author정찬성-
dc.date.accessioned2015-12-03T00:54:29Z-
dc.date.available2015-12-03T00:54:29Z-
dc.date.issued201212-
dc.identifier.citationVOL 84, 198-204-
dc.identifier.issn13811177-
dc.identifier.other38466-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/44082-
dc.description.abstractNatural R-(−)-xanthorrhizol possess a number of therapeutic activities including anti-cancer. The pharmacokinetic properties of that poorly aqueous soluble compound could be improved by incorporating it into polymeric materials. Glycerol can produce a functionalized polymer through a polycondensation process. Enzymatic polycondensation of glycerol and divinylesters was studied and xanthorrhizol was covalently loaded via a butanedioate linker to the polymer backbone. It was observed that xanthorrhizol loading to the polymer backbone increases with the increasing of the chain length of a dioate moiety. Enzyme-mediated xanthorrhizol release from a polymer backbone shows that the polymeric prodrug is able to release xanthorrhizol in a sustained manner. Therefore, the approach described here might be valuable for controlled loading and release of such phenolic sesquiterpenes from the polymeric prodrug.-
dc.publisherJournal of molecular catalysis. B, Enzymatic-
dc.subjectEnzyme-
dc.subjectPolycondensation-
dc.subjectPendant group loading-
dc.subjectDrug delivery system-
dc.subjectXanthorrhizol-
dc.titleSynthesis of poly (glycerol-co-dioate-co-butanedioate-co-xanthorrhizol) ester and a study of chain length effect on pendant group loading-
dc.typeArticle-
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