Evaluation of CdSe/CdS-PEG-FA quantum dots: distribution and observable-adverse-effect-level in mice after intravenous injection

Title
Evaluation of CdSe/CdS-PEG-FA quantum dots: distribution and observable-adverse-effect-level in mice after intravenous injection
Authors
마무눌 하크임혜연서지은마흐법하산Sailendra Nath Sarma우경자권오승
Keywords
CdSe/CdS-PEG-FA QDs; tissue distribution; observable-adverse-effect-level; mice; intravenous injection; CdSe/CdS-PEG-FA quantum dots
Issue Date
2012-08
Publisher
Journal of Pharmaceutical Investigation
Citation
VOL 42, NO 4, 203-212
Abstract
Tissue distribution and observable-adverseeffect- level of cadmium selenide/cadmium sulfide (CdSe/ CdS) quantum dots (QDs) were investigated to get important information of this QDs. Female BALB/c mice were treated with single intravenous (IV) injection of polyethylene glycol-folic acid-coated QDs (CdSe/CdSPEG- FA) at different concentrations (0, 270, and 540 pmol/20 g of mice body weight), and the subsequent toxicological effect-levels were examined for 24 h. The health and apparent behaviors of the animals were normal throughout the study. The distribution of the QDs was observed in the spleen, liver, lung and kidneys, but not in the brain and heart tissues. The spleen and liver possess the highest amount of the QDs followed by the lung while the kidneys possess the few. There were no changes in the organ weight index, total protein concentration, LDH activity, and specific NADPH oxidase activity in any tested organ indicating no toxic effects of the QDs in our study. Additionally, histopathological examination did not show any cellular/tissue structural damages. Overall, single IV administration of CdSe/CdS-PEG-FA QDs to BALB/c mice allows immediate systematic availability, and showed different tissue distribution without any obvious toxic effects at our experimental design.
URI
http://pubs.kist.re.kr/handle/201004/44099
ISSN
20935552
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE