Change of local and global synchronization of gamma oscillations in relation to the depth of ketamine/xylazine anesthesia in MICE

Title
Change of local and global synchronization of gamma oscillations in relation to the depth of ketamine/xylazine anesthesia in MICE
Authors
황은진최지현
Keywords
EEG; GAMMA; SYNCHRONY
Issue Date
2012-10
Publisher
SOCIETY FOR NEUROSCIENCE
Abstract
Gamma oscillations have been proposed to account for cortical information integration process to build coherent percept, and disruption of gamma oscillation was reported to occur concomitantly in psychiatric disorders such as schizophrenia. We have investigated changes of local and global synchronization of gamma oscillations throughout ketamine/xylazine anesthesia and recovery in mice. Electroencephalograms (EEGs) were recorded from two cortical sites of primary somatosensoty cortex (S1) and primary motor cortex (M1), and local field potentials (LFPs) were recorded from two thalamic regions of ventral posteromedial (VPM) nucleus and ventral lateral (VL) nucleus, which has anatomical connections with S1 and M1, respectively. Level of local synchronization of gamma oscillation was estimated by gamma rhythm (35~45 Hz) power of EEG/LFP, and level of global synchronization was calculated using phase synchronization of filtered gamma oscillations between signals recorded from two different regions. During the recording session, physical activity of the animal was monitored via accelerometer based motion sensor and used as reference points of behavior transition to anesthesia and to wakefulness. During the anesthesia, we have observed that while the local synchronization level of gamma oscillation was not significantly different from the baseline level (in M1 and VL) or slightly lower than the baseline (in S1 and VPM), global phase synchronization level was significantly reduced only in the cortical pair. These impaired levels of local and global synchronization started to retrieve before the animal regained its motion. Our results provide an evidence that long-range information integration between cortical regions is important to be conscious. Another interesting thing to note is that in the period between the anesthetic drug administration and the animal’s loss of motion, gamma rhythm power surged up to 2
URI
http://pubs.kist.re.kr/handle/201004/44190
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KIST Publication > Conference Paper
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