Radiosynthesis and Biodistribution of an 125I-labeled Resveratrol Derivative

Title
Radiosynthesis and Biodistribution of an 125I-labeled Resveratrol Derivative
Authors
김성규이웅산한상진김은정모하메드엘가말김병수최태현최창운함인혜오창현최호연조정혁
Keywords
Radiosynthesis; Resveratrol; Iodoresveratrol; Biodistribution; Imaging agent
Issue Date
2012-02
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 33, NO 2, 489-491
Abstract
An 125I-labeled resveratrol derivative 1 was synthesized. It was purified by reverse phase HPLC. Radiochemical purity of the product was more than 98%, and the yield was 35% (decay-corrected). Its biodistribution in tumorbearing mice was studied. The results showed that the highest radioactivity was located in intestine and stomach. The biodistribution profile suggests that compound 1 can be effectively used as a promising imaging probe for intestine and stomach.
URI
http://pubs.kist.re.kr/handle/201004/44256
ISSN
02532964
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KIST Publication > Article
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