Long-term theranostic hydrogel system for solid tumors
- Long-term theranostic hydrogel system for solid tumors
- 김장일; 이범석; 전창주; 조정교; 김상윤; 송수창
- Phosphazene; Long-term theragnosis; Contrast agents; Sustained release; Drug delivery system
- Issue Date
- VOL 33, NO 7, 2251-2259
- The long-term theranostic hydrogel system for solid tumors was prepared via simple physical mixing,
which consisted of three major parts: the thermosensitive/biodegradable poly(organophosphazene)
hydrogel, PEGylated cobalt ferrite nanoparticles, and paclitaxel (PTX). The PEGylated cobalt ferrite
nanoparticles showed extremely low cytotoxicity due to the surface modification using PEG chains. The
long-term theranostic hydrogel system showed adequate properties to be used for long-term MR theragnosis.
In particular, the theranostic hydrogel gradually degraded over 28 days, and the PTX was
sustainedly released out from the theranostic hydrogel over the same period in vitro. Furthermore, the
in vivo efficacy of long-term MR theragnosis using the theranostic hydrogel system was estimated
successfully over 3 weeks by using high field (4.7 T) animal MRI and solid tumor-bearing mice. Based on
our results, we expect that this system can supply multiple data regarding a) the progress of therapy and
b) the treatment processes via one- or two-time i.t. administration for cases in which surgical approaches
are difficult to apply. Meanwhile, cancer patients can be free from the pain of multiple surgical treatments
and have the advantage of therapy through a simple i.t. administration.
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