Long-term theranostic hydrogel system for solid tumors

Title
Long-term theranostic hydrogel system for solid tumors
Authors
김장일이범석전창주조정교김상윤송수창
Keywords
Phosphazene; Long-term theragnosis; Contrast agents; Sustained release; Drug delivery system
Issue Date
2012-03
Publisher
Biomaterials
Citation
VOL 33, NO 7, 2251-2259
Abstract
The long-term theranostic hydrogel system for solid tumors was prepared via simple physical mixing, which consisted of three major parts: the thermosensitive/biodegradable poly(organophosphazene) hydrogel, PEGylated cobalt ferrite nanoparticles, and paclitaxel (PTX). The PEGylated cobalt ferrite nanoparticles showed extremely low cytotoxicity due to the surface modification using PEG chains. The long-term theranostic hydrogel system showed adequate properties to be used for long-term MR theragnosis. In particular, the theranostic hydrogel gradually degraded over 28 days, and the PTX was sustainedly released out from the theranostic hydrogel over the same period in vitro. Furthermore, the in vivo efficacy of long-term MR theragnosis using the theranostic hydrogel system was estimated successfully over 3 weeks by using high field (4.7 T) animal MRI and solid tumor-bearing mice. Based on our results, we expect that this system can supply multiple data regarding a) the progress of therapy and b) the treatment processes via one- or two-time i.t. administration for cases in which surgical approaches are difficult to apply. Meanwhile, cancer patients can be free from the pain of multiple surgical treatments and have the advantage of therapy through a simple i.t. administration.
URI
http://pubs.kist.re.kr/handle/201004/44281
ISSN
01429612
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KIST Publication > Article
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