Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold

Title
Design, synthesis, and preliminary cytotoxicity evaluation of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold
Authors
최원경모하메드엘가말최홍석홍준희백대진최기항오창현
Keywords
A375P; Anticancer; Diarylamide; Diarylurea; 1,3,4-Triarylpyrazole
Issue Date
2012-09
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 33, NO 9, 2991-2998
Abstract
A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3- (trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.
URI
http://pubs.kist.re.kr/handle/201004/44300
ISSN
02532964
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE