Dendrobium moniliforme Attenuates High-Fat Diet-Induced Renal Damage in Mice through the Regulation of Lipid-Induced Oxidative Stress
- Dendrobium moniliforme Attenuates High-Fat Diet-Induced Renal Damage in Mice through the Regulation of Lipid-Induced Oxidative Stress
- 이우정; 엄대운; 정유정; Noriko Yamabe; 이승용; 전영식; 황예란; 이지환; 김용기; 강기성; 김수남
- Dendrobium moniliforme; High fat diet; Renal damage; Oxidative stress; Obesity; Antioxidant; Kidney
- Issue Date
- The American journal of Chinese medicine
- VOL 40, NO 6, 1217-1228
- Obesity is an important and preventable risk factor for renal disease. The administration
of an antioxidant with a lipid-lowering effect is an important therapeutic approach
for kidney disease in obese patients. The present study was conducted to examine whether
methanolic extract of Dendrobium moniliforme (DM), one of the most famous traditional
medicines used in many parts of the world, has an antioxidant effect in vitro and an ameliorative
effect on high-fat diet (HFD)-induced alterations such as renal dysfunction and lipid
accumulation in vivo. The 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of DM
extract (IC50 = 29:6 μg/mL) was increased in a dose-dependent manner. The LLC-PK1
kidney cell damage induced by oxidative stress was significantly inhibited by the treatments
with DM extract. In the animal study, DM extract (200 mg/kg) was orally administered every
day for nine weeks to HFD-fed mice, and its effect was compared with that of metformin.
The administration of DM extract decreased the elevated serum glucose, total cholesterol
concentration and renal lipid accumulation in HFD-fed mice. It also ameliorated renal
dysfunction biomarkers including serum creatinine and renal collagen IV deposition. Taken
together, these results provide important evidence that DM extract exhibits a pleiotropic
effect on obesity induced parameters and exerted a renoprotective effect in HFD-fed mice.
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