Fast Myoglobin Detection Using Nanofluidic Electrokinetic Trapping Technique

Title
Fast Myoglobin Detection Using Nanofluidic Electrokinetic Trapping Technique
Authors
천동원Sang Hui Kim송형완Seungmin Kwak김유찬석현광Sang Myung LeeJeong Hoon Lee
Keywords
Myoglobin detection; nanofluidics; Electrokinetic trapping
Issue Date
2013-01
Publisher
Applied Physics Express
Citation
VOL 6, 017001-1-017001-3
Abstract
We report on the preconcentration-enhanced fast collection of myoglobin protein for the rapid detection of myocardial infarction. We use a onedimensional micro/nanofluidic chip for electrokinetic preconcentration and demonstrate that the preconcentration factor of 1 ng/ml Alexa Fluor 488-labeled myoglobin is ~1000 within 200 s, where the protein had a weak negative charge, thereby making it hard to perform electrokinetic trapping for neutral-like proteins. The potential feasibility with new assay strategies for use in a rapid immunoassay screening test for myocardial infarction is discussed.
URI
http://pubs.kist.re.kr/handle/201004/44423
ISSN
18820778
Appears in Collections:
KIST Publication > Article
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