Effects of fermented ginseng on memory impairment and β-amyloid reduction in Alzheimer's disease experimental models
- Effects of fermented ginseng on memory impairment and β-amyloid reduction in Alzheimer's disease experimental models
- 김준기; 김성훈; 이득식; 이동진; 김수현; 정성권; 양현옥
- Panax ginseng; Fermented ginseng; Alzheimer's disease; Beta-amyloid; Animal model
- Issue Date
- Journal of Ginseng Research
- VOL 37, NO 1, 100-107
- This study examined the effect of fermented ginseng (FG) on memory impairment and β-amyloid (Aβ) reduction in models of
Alzheimer’s disease (AD) in vitro and in vivo. FG extract was prepared by steaming and fermenting ginseng. In vitro assessment
measured soluble Aβ42 levels in HeLa cells, which stably express the Swedish mutant form of amyloid precursor protein. After 8
h incubation with the FG extract, the level of soluble Aβ42 was reduced. For behavioral assessments, the passive avoidance test
was used for the scopolamine-injected ICR mouse model, and the Morris water maze was used for a transgenic (TG) mouse model,
which exhibits impaired memory function and increased Aβ42 level in the brain. FG extract was treated for 2 wk or 4 mo on ICR
and TG mice, respectively. FG extract treatment resulted in a significant recovery of memory function in both animal models. Brain
soluble Aβ42 levels measured from the cerebral cortex of TG mice were significantly reduced by the FG extract treatment. These
findings suggest that FG extract can protect the brain from increased levels of Aβ42 protein, which results in enhanced behavioral
memory function, thus, suggesting that FG extract may be an effective preventive or treatment for AD.
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