Water-soluble polysaccharides from the brown alga Eisenia bicyclis: Structural characteristics and antitumor activity
- Water-soluble polysaccharides from the brown alga Eisenia bicyclis: Structural characteristics and antitumor activity
- Ermakova Svetlana; Menshova Roza; Vishchuk Olesya; 김상민; 엄병헌; Isakov Vladimir; Zvyagintseva Tatyana
- Brown Alga; Laminarans; Fucoidans; Structure; Anticancer activity
- Issue Date
- Algal Research
- VOL 2, NO 1, 51-58
- Water-soluble polysaccharides were isolated from the brown alga Eisenia bicyclis, which was collected near
the coast of the Republic of Korea. The structures of laminaran and fucoidan were investigated. Laminaran
from E. bicyclis was determined to be a glucan with β-(1→6) side chains linked to a β-(1→3) backbone
with relatively few branch points. Based on nuclear magnetic resonance (NMR) data, the ratio of the
β-(1→3) and β-(1→6) linkages was estimated as 2.6:1. Fucoidan from E. bicyclis was found to contain
1,3-linked fucose residues, some 1,6-, 1,2,6-, 1,4,6-linked galactose residues and traces of mannose and xylose.
In addition, the amount of sulfate in fucoidan was 13.2%. Those polysaccharides were non-cytotoxic to
human melanoma SK-MEL-28 and colon cancer DLD-1 cells. Laminaran and fucoidan from E. bicyclis inhibited
the colony formation of those cells. Therefore, they may have potential as antitumor agents.
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