The association between some endocrine disruptors in human plasma and the occurrence of congenital hypothyroidism
- The association between some endocrine disruptors in human plasma and the occurrence of congenital hypothyroidism
- 정현주; Yonghee Hong; Donghwan Lee; Kijung Pang; 김연제
- congenital hypothyrodism; endocrine disruptors; Isoflavones; Association; human plasma; GC?MS
- Issue Date
- Environmental toxicology and pharmacology
- VOL 35, NO 2, 278-283
- Congenital hypothyroidism is a common pediatric endocrine disease. Endocrine disruptors
are indicated as a possible cause of congenital hypothyroidism. We investigated the associations
between endocrine disruptors and the occurrence of congenital hypothyroidism
and passage of target compounds from the mother. The levels of phthalates (DEHP, MEHP,
DBP, MBP and PA), alkylphenols (n-NP and t-OP), bisphenol, and isoflavones (equol, daidzein
and genistein) were determined by gas chromatography–mass spectrometry (GC–MS) in
infants. t-OP and PA concentrations in the patient group were significantly higher than in
normal infants. Genistein concentrations in normal infants were significantly higher than
in patients. We compared the plasma levels of target compounds in infants with their mothers.
There was no correlation with the passage of endocrine disruptors and isoflavones from
the mothers, except for t-OP, which was weakly correlated between mother and infant.
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