Multifunctionalized Cantilever Systems for Electronic Nose Applications

Title
Multifunctionalized Cantilever Systems for Electronic Nose Applications
Authors
유용경채명식강지윤김태송황교선이정훈
Keywords
Cantilever; Multiplexing; E-nose
Issue Date
2012-10
Publisher
Analytical chemistry
Citation
VOL 84, NO 19, 8240-8245
Abstract
Multiple target detection using a cantilever is essential for biosensor, chemical sensor, and electronic nose systems. We report a novel microcantilever array chip that includes four microreaction chambers in a chip, which consequently contains four different functionalized surfaces for multitarget detection. For model tests, we designed microcantilever chips and demonstrated the ability of binding of 2,4-dinitrotoluene (DNT) targets onto four different surfaces. We used peptide receptors that are known to have highly selective binding. By simply using four microreaction chambers, we immobilized DNT specific peptide (HPNFSKYILHQRC; SP), DNT nonspecific peptide (TSMLLMSPKHQAC; NSP), and self-assembled monolayer (SAM) as well as a bare cantilever. After flowing DNT gases through the cantilever chip, we could monitor the four different binding signals simultaneously. The shifts in NSP provided information as a negative control because it contained information of temperature fluctuations and mechanical vibration from gas flow. By utilizing the differential signal of the SP and NSP, we acquired 7.5 Hz in resonant responses that corresponds with 160 part per billion (ppb) DNT concentration, showing the exact binding response by eliminating the inevitable thermal noise, vibration noise, as well as humidity effects on the peptide surface.
URI
http://pubs.kist.re.kr/handle/201004/44659
ISSN
00032700
Appears in Collections:
KIST Publication > Article
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