Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice

Title
Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice
Authors
Bergstrom RA최지현Manduca A신희섭Worrell GAHowe CL
Issue Date
2013-03
Publisher
Scientific Reports
Citation
VOL 3, 1483-1-1483-8
Abstract
Visual scoring of murine EEG signals is time-consuming and subject to low inter-observer reproducibility. The Racine scale for behavioral seizure severity does not provide information about interictal or sub-clinical epileptiform activity. An automated algorithm for murine EEG analysis was developed using total signal variation and wavelet decomposition to identify spike, seizure, and other abnormal signal types in single-channel EEG collected from kainic acid-treated mice. The algorithm was validated on multi-channel EEG collected from c-butyrolacetone-treated mice experiencing absence seizures. The algorithm identified epileptiform activity with high fidelity compared to visual scoring, correctly classifying spikes and seizures with 99% accuracy and 91% precision. The algorithm correctly identifed a spike-wave discharge focus in an absence-type seizure recorded by 36 cortical electrodes. The algorithm provides a reliable and automated method for quantification of multiple classes of epileptiform activity within the murine EEG and is tunable to a variety of event types and seizure categories.
URI
http://pubs.kist.re.kr/handle/201004/44675
ISSN
20452322
Appears in Collections:
KIST Publication > Article
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