Increase in biological activities of ginsenoside Re by maillard reaction
- Increase in biological activities of ginsenoside Re by maillard reaction
- 김영주; 이승용; 강기성
- Ginsenoside; Maillard reaction; Biological activity; Antioxidant
- Issue Date
- 2013년 고려인삼학회 춘계학술대회
- Purpose: The aim of the present study was to identify changes in the structure, antioxidant and anticancer effects of
ginsenoside Re, major triol type ginsenosides of Panax ginseng, upon Maillard reaction. Methods: Ginsenoside Re
was heat-processed with lysine and its structural change was confirmed by using preparative HPLC and spetrometric
methods. Antioxidant effect was tested by DPPH assay, and anticancer activity was tested in AGS human gastric
cancer cells. Resulb: Ginsenoside Re was transformed into less-polar ginsenosides, namely Rg2, Rg6 and F4 by
heat-processing. Free radical-scavenging activity of the ginsenoside Re-lysine mixture increased upon heat processing.
The improved free radical-scavenging activity mediated by antioxidant MRPs, which were generated through Maillard
reaction ofa glucosyl moiety separated from carbon-20 ofginsenoside Re and lysine. The increased anticancer effect
of ginsenoside Re-lysine mixture upon heat processing was mainly derived from the generation of less-polar
ginsenosides through the regulation of Bcl-2 and Bax, as well as caspase-dependent apoptotic pathway. Conclusion:
These results reported here have shed significant lights on the mechanism of increased antioxidant and anticancer
effects of Panax ginsengby heat processing.
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