Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model

Title
Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model
Authors
김현진김혜연Hanna Erlich최선영김동진김영수
Keywords
뇌질환; Brain Disorders; Sulforaphane; Acute AD animal model; Alzheimer's disease; amyloid-β; cell viability assay; passive avoidance test; reactive oxygen species; Y-maze test
Issue Date
2013-03
Publisher
Amyloid : The Journal of Protein Folding Disorders
Citation
VOL 20, NO 1, 7-12
Abstract
Pathophysiological evidences of AD have indicated that aggregation of Aβ is one of the principal causes of neuronal dysfunction, largely by way of inducing oxidative stresses such as free radical formation. We hypothesized that the known antioxidative attribute of SFN could be harnessed in Alzheimer’s treatment. SFN is an indirect, potent antioxidant derived from broccoli that has previously been found to stimulate the Nrf2-ARE pathway and facilitate several other cytoprotective mechanisms. In this study, administration of SFN ameliorated cognitive function of Aβ-induced AD acute mouse models in Y-maze and passive avoidance behavior tests. Interestingly, we found that the therapeutic effect of SFN did not involve inhibition of Aβ aggregation. While the exact mechanism of interaction of SFN in AD has not yet been ascertained, our results suggest that SFN can aid in cognitive impairment and may protect the brain from amyloidogenic damages.
URI
http://pubs.kist.re.kr/handle/201004/44762
ISSN
13506129
Appears in Collections:
KIST Publication > Article
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