Cortical Source Localization of Mouse Extracranial Electroencephalogram using the Fieldtrip Toolbox

Title
Cortical Source Localization of Mouse Extracranial Electroencephalogram using the Fieldtrip Toolbox
Authors
이충기Robert Oostenveld이수현김래현Hokun Sung최지현
Issue Date
2013-07
Publisher
IEEE Engineering in Medicine and Biology Society (EMBC)
Abstract
Neuronal source estimation is a general tool for analyzing spatiotemporal dynamics in human EEG. Despite rapidly-evolving interest in human brain, there are few EEG based source estimation tools in rodent brain. Therefore, we implemented source estimation tool in a mouse model, using the FieldTrip open-source software. High resolution EEGs with a known cortical source were recorded with a recently developed 40-channel polyimide-based microelectrode under optical stimulation on optogenetially engineered mice. To obtain realistic mouse head models, the volume conduction model was extracted from in vitro mouse brain MRIs. Segmented compartments (skin and outer/inner skull) were used to form triangular meshes and then applied to the boundary element method. The high-resolution EEGs recorded during various optogenetic stimulation of the mouse brain were inversely source reconstructed using minimumnorm estimate. Estimated source locations and strengths were reconstructed, and their error was calculated to evaluate FieldTrip-based source localization algorithm. In summary, source localization imaging of the mouse brain was successfully achieved, using freely-available open source software. This will be useful to investigate the functional dynamics of mouse brain in noninvasive measure.
URI
http://pubs.kist.re.kr/handle/201004/44903
Appears in Collections:
KIST Publication > Conference Paper
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