Antioxidant activities of the EtOAC fraction and active compounds from Taraxacum coreanum under cellular system and in vivo
- Antioxidant activities of the EtOAC fraction and active compounds from Taraxacum coreanum under cellular system and in vivo
- Eun Ju Cho; Ah Young Lee; Sanghyun Lee; Hyun Young Kim; 강기성; Noriko Yamabe
- Taraxacum coreanum; Antioxidant
- Issue Date
- Experimental Biology 2013
- We evaluated protective activity of the EtOAc fraction and active
compounds, luteolin (LT) and luteoloside (LS), from Taraxacum
coreanum NAKAI, one of the native plant in Korea, against nitric
oxide (NO) and Aβ25-35. The LLC-PK1 renal epithelial cells showed
declines in cell viability and increase in NO formation through
oxidative stress induced by sodium nitroprusside (SNP). However,
the treatment of the EtOAc fraction, LT and LS significantly
increased cell viability and decreased NO formation. Furthermore,
NO formation and lipid peroxidation were significantly elevated in
the mouse injected with Aβ25-35, whereas the groups administered
the EtOAc fraction of T. coreanum, inhibited dose-dependently
lipid peroxidation and NO production in the brain, liver and kidney.
These results indicated that the EtOAc fraction contains the
bioactive compounds with protective effect against NO and Aβ25-35.
In addition, LT and LS from T. coreanum are beneficial in
preventing oxidative damage from free radical.
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