Nocapyrones H-J, 3,6-Disubstituted α-Pyrones from the Marine Actinomycete Nocardiopsis sp. KMF-001

Title
Nocapyrones H-J, 3,6-Disubstituted α-Pyrones from the Marine Actinomycete Nocardiopsis sp. KMF-001
Authors
김민철권오욱박진수김선여권학철
Keywords
nocapyrone H; nocapyrone I; nocapyrone J; Nocardiopsis sp.; neuro-protective effect
Issue Date
2013-05
Publisher
Chemical & pharmaceutical bulletin
Citation
VOL 61, NO 5, 511-515
Abstract
Three new 3,6-disubstituted α-pyrones, nocapyrones H–J (1–3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2Hpyran- 2-ones on the basis of UV, MS, NMR, and high resolution (HR)-FAB-MS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E2 (PGE2) and interleukin-1β (IL-1β). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 μm in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.
URI
http://pubs.kist.re.kr/handle/201004/44959
ISSN
00092363
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KIST Publication > Article
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