A polyacetylene-rich extract from Gymnaster koraiensis strongly inhibits colitis-associated colon cancer in mice

Title
A polyacetylene-rich extract from Gymnaster koraiensis strongly inhibits colitis-associated colon cancer in mice
Authors
Shannon M. ButlerMatthew A. Wallig노주원판철호이은하정상훈Elizabeth H. Jeffery
Keywords
Azoxymethane; Colon cancer; Dextran sulfate sodium; Prevention; Inflammation; Polyacetylene
Issue Date
2013-03
Publisher
Food and chemical toxicology
Citation
VOL 53, 235-239
Abstract
Gymnaster koraiensis (GK) is a Korean herb used in folk medicine and recently found to positively impact liver health. Because GK contains polyacetylenes and because other polyacetylenes have been found to exhibit anti-inflammatory and anti-cancer activities, we hypothesized that the polyacetylene gymnasterkoreayne B (GKB), known to increase hepatic detoxification enzymes, may also exert anti-inflammatory and anti-cancer activities. We fed male C57BL/6 mice purified AIN93G diets containing no additions, GKB or the GKB-rich fraction of an ethanol extract (GE) from GK to determine if these diets would slow or prevent either inflammation or inflammation-enhanced colon cancer, using the dextran sulfate sodium/azoxymethane mouse model. The GKB (500 μmol/kg diet daily) showed some antiinflammatory activity, but GE, containing an equal dose of GKB, protected strongly against both inflammation and colon cancer, decreasing adenocarcinomas by 90%. These data support further research into GK as a promising potential anti-cancer agent.
URI
http://pubs.kist.re.kr/handle/201004/44990
ISSN
02786915
Appears in Collections:
KIST Publication > Article
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