Evaluation of Anti-inflammatory Activities and Mechanisms of Microalga Phaeodactylum tricornutum

Title
Evaluation of Anti-inflammatory Activities and Mechanisms of Microalga Phaeodactylum tricornutum
Authors
Jeong Hwa Kim김상민판철호Joong-Kook ChoiJae Kwon Lee
Keywords
anti-inflammation; cytokine; marine resources; Phaeodactylum tricornutum
Issue Date
2013-06
Publisher
Journal of Applied Biological Chemistry
Citation
VOL 56, NO 2, 61-67
Abstract
Due to their diversity and abundancy, marine resources have emerged as important biological resources to compensate the limited sources of terrestrial biological materials. Phaeodactylum tricornutum (PT) is one of classical model diatoms most widely studied for its ecology, physiology, biochemistry and molecular biology. In this study, four different PT extracts on lipopolysaccharide (LPS)-stimulated macrophages were compared for anti-inflammatory effect and investigated for the underlying mechanisms. The extracts of PT inhibited nitric oxide production from LPS stimulated RAW 264.7 cells in a dose dependent manner. These extracts also inhibited the expression of mRNA and production of proteins of pro-inflammatory cytokines such as interleukin (IL)- 1β, IL-6 and tumor necrosis factor-α. These inhibitory effects were found to be caused by blockage of nuclear factor-κB activation and phosphorylation of p38 mitogen-activated protein kinases, extracellular signal-regulated kinases 1 and 2 and c-Jun N-terminal kinase.
URI
http://pubs.kist.re.kr/handle/201004/45002
ISSN
19760442
Appears in Collections:
KIST Publication > Article
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