Potassium (1-Organo-1H-1,2,3-triazol-4-yl)trifluoroborates from Ethynyltrifluoroborate through a Regioselective One-Pot Cu-Catalyzed Azide-Alkyne Cycloaddition Reaction

Title
Potassium (1-Organo-1H-1,2,3-triazol-4-yl)trifluoroborates from Ethynyltrifluoroborate through a Regioselective One-Pot Cu-Catalyzed Azide-Alkyne Cycloaddition Reaction
Authors
김태정송중호정규혁이석준함정엽
Keywords
Copper; Click chemistry; Boron; Nitrogen heterocycles; Cross-coupling
Issue Date
2013-07
Publisher
European journal of organic chemistry
Citation
VOL 2013, NO 19, 3992-3996
Abstract
A novel series of 1,4-disubstituted 1,2,3-triazole-containing potassium trifluoroborates were prepared in good to excellent yields from the corresponding organohalides and potassium ethynyltrifluoroborate through a regioselective one-pot Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction. Further Suzuki–Miyaura cross-coupling of these (organo-1,2,3-triazol-4-yl)trifluoroborates with aryl and alkenyl bromides by using a PdCl2(dppf)·CH2Cl2/TBAB [dppf = 1,1′-bis(diphenylphosphanyl)ferrocene, TBAB = tetrabutylammonium bromide] system under microwave irradiation was explored.
URI
http://pubs.kist.re.kr/handle/201004/45073
ISSN
1434193X
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KIST Publication > Article
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