Hydrophobicity and non-thrombogenicity of nanoscale dual rough surface coated with fluorine-incorporated diamond-like carbon films: Biomimetic surface for blood-contacting medical devices
- Hydrophobicity and non-thrombogenicity of nanoscale dual rough surface coated with fluorine-incorporated diamond-like carbon films: Biomimetic surface for blood-contacting medical devices
- T. Hasebe; So Nagashima; A. Kamijo; 문명운; Y. Kashiwagi; A. Hotta; 이광렬; K. Takahashi; T. Yamagami; T. Suzuki
- DLC; Hydrophobicity; Blood compatibility; FDLC; Nanoscale dual rough surface; Diamond-like carbon; Biomimetic surface; Non-thrombogenicity
- Issue Date
- Diamond and related materials
- VOL 38, 14-18
- We investigated the hydrophobicity and non-thrombogenicity of a nanoscale dual rough surface coated with
hydrophobic and non-thrombogenic fluorine-incorporated diamond-like carbon (F-DLC) films. We prepared
Si (1 0 0) and a dual rough surface composed of coarse posts and nano-sized fine posts as substrates. DLC film
was deposited on the Si substrate, and F-DLC film was deposited on Si or the dual rough surface using radio
frequency plasma enhanced chemical vapor deposition method. The surface hydrophobicity of each sample
was examined with water contact angle measurements and the non-thrombogenicity was evaluated through
incubation with platelet-rich plasma isolated from human whole blood.
The water repellency was dramatically improved on the F-DLC-coated dual rough surface compared with that
on DLC-coated Si or F-DLC-coated Si, which had a water contact angle of 130.6°. There was no significant difference
in the values for the platelet-covered area between DLC-coated Si and the F-DLC-coated dual rough
surface. As DLC is being considered for widespread clinical use as a surface coating for medical devices
owing to its non-thrombogenicity compared with other biomaterials, the F-DLC-coated dual rough surface
presented in this study still has the potential for clinical use, such as temporary blood-contacting medical devices,
to take advantage of its high hydrophobicity.
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