Bacteriophages as Templates for Manufacturing Supramolecular Structures
- Bacteriophages as Templates for Manufacturing Supramolecular Structures
- Korkmaz, Nuriye; Kim, Young Jun; Nam, Chang Hoon
- apatite-like materials; biomineralization; electron
microscopy; metallization; phage bundles
- Issue Date
- Macromolecular bioscience
- VOL 13, NO 3, 376-387
- SS phages are genetically enginnered by replacing 2 N-terminal amino acids of the p8 coat
protein of the fd phage. AGE and zeta potential measurements show that SS phages carry at
least 1/4 less net negative surface charge than fd phages. Morphology and thickness of phages are studied at different counterion concentrations (10-3, 10-2 and 10-1 M) by AFM, SEM and immunofluorescence analyses. Bundles induced by CoCl2 and CaCl2 are either metallized by chemical reduction or biomineralized for apatite-like material formation.
EDX spectroscopy confirms the presence of Co, P and Ca peaks in mineralized samples. Such bottom-up manufactured phage scaffolds might be applied in bioengineering studies.
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