Amorphastilbol derived from Amorpha fruticosa : Total synthesis and biological evaluation of dual PPAR α/γ agonist

Title
Amorphastilbol derived from Amorpha fruticosa : Total synthesis and biological evaluation of dual PPAR α/γ agonist
Authors
김태정이우정정규혁최필주김수남이석준Masaya Nakata함정엽
Keywords
Amorphastilbol; Natural Products; PPAR agonist; Total Synthesis; trans-stilbene; Suzuki-Miyaura; Potassium trifluoroborates
Issue Date
2013-07
Publisher
18th European Symposium of Organic Chemistry
Abstract
Peroxisome proliferator–activated receptors (PPARs) are ligand-activated transcription factors involved in the transcriptional regulation of key metabolic pathways such as lipid metabolism, adipogenesis, and insulin sensitivity. Three PPAR isotypes have been identified α, γ, and δ. The amorphastilbol (APH-1) is a small molecules of natural stilbene isolated from the Amorpha fruticosa, and stimulates PPARα/γ transcriptional activity at the lower concentration than previously reported natural PPARs ligands. Therefore, we focused on the total synthesis of APH-1 from RPU extract (0.04% yield) and its derivatives and their biological evaluation as PPAR transcriptional activators.
URI
http://pubs.kist.re.kr/handle/201004/45219
Appears in Collections:
KIST Publication > Conference Paper
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