Mechanical Properties of Compliant Double Layered Poly(L-lactide-co-ε-caprolactone) Vascular Graft

Title
Mechanical Properties of Compliant Double Layered Poly(L-lactide-co-ε-caprolactone) Vascular Graft
Authors
김상훈문초혜정영미김상헌김동익김수현
Keywords
poly(L-lactide-co-ε-caprolactone); gel-spinning molding technique; double-layered scaffold; dynamic compliance; vascular tissue engineering
Issue Date
2013-08
Publisher
Macromolecular research
Citation
VOL 21, NO 8, 886-891
Abstract
We fabricated a tubular double-layered scaffold using two steps; poly(L-lactide-co-ε-caprolactone) (PLCL) gel spinning method and salt leaching. The objective of the present study was to characterize the mechanical properties of tubular double-layered PLCL scaffolds that had different wall thickness values. We evaluated the bio-vascular scaffold in terms of cardiovascular implants-tubular vascular prostheses in international standard; ANSI/ AAMI/ISO 7198:1998/2001. According to the ISP 7198, PLCL had sufficient mechanical strength, burst strength, tensile strength to withstand blood pressure and had similar compliance to native vessels due to its elasticity. We applied the tubular vascular prostheses’ evaluation method using an existing surgical operation. The vascular scaffold, which had a similar compliance to native vessels, did not result in severe thrombosis in vivo for 4 weeks. Thus, this novel material holds great promise for use as a blood vessel substitute.
URI
http://pubs.kist.re.kr/handle/201004/45251
ISSN
15985032
Appears in Collections:
KIST Publication > Article
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