Preparation of enhanced hydrophobic poly(L-lactide-co-ε-caprolactone) films surface and its blood compatibility

Title
Preparation of enhanced hydrophobic poly(L-lactide-co-ε-caprolactone) films surface and its blood compatibility
Authors
김승일임진익정영미김지흥김수현
Keywords
PLCL; Blood compatibility; Surface modification; Porous material; Hydrophobicity
Issue Date
2013-07
Publisher
Applied surface science
Citation
VOL 276, 586-591
Abstract
Hydrophobicity-enhanced poly(l-lactide-co-ε-caprolactone) (PLCL) (50:50) films were cast by using the solvent–nonsolvent casting method. PLCL (50:50) was synthesized by the well-known random copolymerization process and confirmed by 1H NMR analysis. The molecular weight of the synthesized PLCL was measured by gel permeation chromatography (GPC). Number-average (Mn), weight-average (Mw) molecular weights and polydispersity (Mw/Mn) were 7 × 104, 1.2 × 105, and 1.7, respectively. PLCL films were cast in vacuum condition with various nonsolvents and nonsolvent ratios. Tetrahydrofuran (THF) was used as the solvent and three different alcohols were used as the nonsolvent: methanol, ethanol, and isopropyl alcohol (IPA). Surface hydrophobicity was confirmed by water contact angle. The water contact angle was increased from 81° ± 2° to 107° ± 2°. Water contact angle was influenced by surface porosity and topography. The prepared film surfaces were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The change of crystalline property was characterized by X-ray diffraction (XRD). Platelet adhesion tests on the modified PLCL film surfaces were evaluated by platelet-rich plasma (PRP). The modified film surface exhibited enhanced hydrophobicity and reduced platelet adhesion ratio depending on the surface topography. One of the candidate products proposed as a potential blood compatible material showed a markedly reduced platelet adhesion property.
URI
http://pubs.kist.re.kr/handle/201004/45270
ISSN
01694332
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KIST Publication > Article
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