Adsorption, Bioavailability, and Toxicity of Cadmium to Soil Microorganisms

Title
Adsorption, Bioavailability, and Toxicity of Cadmium to Soil Microorganisms
Authors
최재영
Keywords
bioavailability; cadmium; fluorescein diacetate; toxicity
Issue Date
2009-06
Publisher
Geomicrobiology journal
Citation
VOL 26, NO 4, 248-255
Abstract
In this study, we investigated the effects of various histone deacetylase (HDAC) inhibitors on adipocyte differentiation. Treatment of 3T3-L1 cells with HDAC inhibitors such as apicidin, trichostatin A, or suberoylanilide hydroxamic acid, under conditions that normally promote differentiation led to a dramatic attenuation of adipocyte differentiation. In contrast, sodium butyrate (NaB) treatment increased adipocyte differentiation. Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARγ, resistin, C/EBPα, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized. In addition, this differential effect seemed not to be due to disruption of the insulin- signaling pathway. Interestingly, our data showed that apicidin treatment could induce dedifferentiation of fully differentiated adipocytes, as evident by the fact that apicidin treatment led to a decrease of Oil Red O-stained adipocytes with a concomitant reduction in the expression levels of adipogenic marker genes. Collectively, our results suggest that adipocyte differentiation and dedifferentiation may be regulated by HDAC inhibitors.
URI
http://pubs.kist.re.kr/handle/201004/45516
ISSN
0149-0451
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KIST Publication > Article
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