Decreased Expression of the Suppressor of Cytokine Signaling 6 in Human Hepatocellular Carcinoma

Title
Decreased Expression of the Suppressor of Cytokine Signaling 6 in Human Hepatocellular Carcinoma
Authors
배현진노지헌은정우김정규정광화사홍건안영민류재천박원상이정용남석우
Keywords
Cytokine Signaling 6; Human Hepatocellular Carcinoma; SOCS6; Down-regulation
Issue Date
2009-09
Publisher
Molecular & Cellular Toxicology
Citation
VOL 5, NO 3, 193-197
Abstract
Suppressors of cytokine signaling (SOCS) proteins were originally identified as negative feedback regulators of cytokine signaling and include the Janus kinase/ Signal transducer and activator of transcription (JAK/STAT) pathways. Recent studies have shown that SOCS proteins negatively regulate the receptor tyrosine kinase (RTK) pathway including the insulin receptor (IR), EGFR, and KIT signaling pathways. In addition, SOCS1 and SOCS3 have been reported to have anti-tumor effects in human hepatocellular carcinoma (HCC). However, it is uncertain whether other members of the SOCS family are associated with tumor development and progression. In this study, to investigate whether SOCS6 is aberrantly regulated in HCC, we examined the expression level of SOCS6 in HCC by Western blot analysis and immunohistochemical staining. The results showed that SOCS6 was down-regulated in all examined HCCs compared to the corresponding normal tissues. In addition, expression of SOCS6 was observed in the cytoplasm of most normal and precancerous tissue, but not in the HCCs by immunohistochemical staining. This is first report to demonstrate that SOCS6 is aberrantly regulated in HCC. These findings suggest that underexpression of SOCS6 is involved in hepatocarcinogenesis, and SOCS6 may play a role, as a tumor suppressor, in HCC development and progression.
URI
http://pubs.kist.re.kr/handle/201004/45535
ISSN
1738-642X
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KIST Publication > Article
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