6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge

Title
6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge
Authors
최은주권학철함정엽양현옥
Keywords
Phenazine; Marine bacterium; Brevibacterium; Marine sponge; antibiotics; antibacterial activity; 6-Hydroxymethyl-1-phenazine-carboxamide; phenazine; 1,6-phenazinedimethano; sponge
Issue Date
2009-11
Publisher
Journal of antibiotics
Citation
VOL 62, NO 11, 621-624
Abstract
Two new antibacterial phenazines were isolated from the culture broth of Brevibacterium sp. KMD 003 obtained from a marine purple vase sponge of the genus Callyspongia, collected in Kyeongpo, Gangwondo, Korea. The structures of these compounds were determined to be 6-hydroxymethyl-1-phenazine-carboxamide (1) and 1,6-phenazinedimethanol (2) through analyses of HR–EI–MS and NMR data. Compounds 1 and 2 showed antibacterial activities against Enterococcus hirae and Micrococcus luteus with 5 lM MIC values.
URI
http://pubs.kist.re.kr/handle/201004/45540
ISSN
0021-8820
Appears in Collections:
KIST Publication > Article
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