6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge
- 6-Hydroxymethyl-1-phenazine-carboxamide and 1,6-phenazinedimethanol from a marine bacterium, Brevibacterium sp. KMD 003, associated with marine purple vase sponge
- 최은주; 권학철; 함정엽; 양현옥
- Phenazine; Marine bacterium; Brevibacterium; Marine sponge; antibiotics; antibacterial activity; 6-Hydroxymethyl-1-phenazine-carboxamide; phenazine; 1,6-phenazinedimethano; sponge
- Issue Date
- Journal of antibiotics
- VOL 62, NO 11, 621-624
- Two new antibacterial phenazines were isolated from the culture broth of Brevibacterium sp. KMD 003 obtained from a marine
purple vase sponge of the genus Callyspongia, collected in Kyeongpo, Gangwondo, Korea. The structures of these compounds
were determined to be 6-hydroxymethyl-1-phenazine-carboxamide (1) and 1,6-phenazinedimethanol (2) through analyses of
HR–EI–MS and NMR data. Compounds 1 and 2 showed antibacterial activities against Enterococcus hirae and Micrococcus
luteus with 5 lM MIC values.
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