Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo
- Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo
- 이슬기; 류주희; 박경순; 이애주; 이승영; 윤인찬; 안철희; 윤순만; 명승재; 문대혁; Xiaoyuan Chen; 최귀원; 권익찬; 김광명
- Issue Date
- Nano letters
- VOL 9, NO 12, 4412-4416
- We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled
matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the
nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor
in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of
biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.
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