Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

Title
Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo
Authors
이슬기류주희박경순이애주이승영윤인찬안철희윤순만명승재문대혁Xiaoyuan Chen최귀원권익찬김광명
Issue Date
2009-12
Publisher
Nano letters
Citation
VOL 9, NO 12, 4412-4416
Abstract
We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.
URI
http://pubs.kist.re.kr/handle/201004/45541
ISSN
1530-6984
Appears in Collections:
KIST Publication > Article
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