Salvianolic Acid A Inhibits Scar Formation by Interfering with the Activation of Macrophage and Fibroblast

Title
Salvianolic Acid A Inhibits Scar Formation by Interfering with the Activation of Macrophage and Fibroblast
Authors
김건웅김도훈낫트롱판조경환양범석
Keywords
Salvianolic acid A; Scar; Dermal fibroblast; Macrophage
Issue Date
2009-11
Publisher
대한창상학회지 (J Korean Wound Management Soc)
Citation
VOL 5, NO 2, 79-87
Abstract
When Salvianolic acid A isolated from Danshen was applied for the full-excisional wound model in rabbit ear and rat dorsal skin, it showed a biological activity to diminish the scar formation. This activity was correlated with the suppression of macrophage activation. Salvianolic acid A treatment could suppress the stress-related signaling pathways in J774A.1 mouse macrophage cells which was activated by LPS. This suppression was correlated with the inhibition of inducible nitric oxide synthetase expression and focal adhesion kinase activation. In addition Salvianolic acid treatment inhibited the proliferation and migration of rat dermal fibroblast with the reduction of alpha smooth muscle actin expression. Taken together these data suggest that Salvianolic acid A can suppress the scar formation by interfering with the activating signaling pathways of dermal fibroblast and macrophage in wound healing process.
URI
http://pubs.kist.re.kr/handle/201004/45547
ISSN
1738-8597
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KIST Publication > Article
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