Salvianolic Acid A Inhibits Scar Formation by Interfering with the Activation of Macrophage and Fibroblast
- Salvianolic Acid A Inhibits Scar Formation by Interfering with the Activation of Macrophage and Fibroblast
- 김건웅; 김도훈; 썬; 낫트롱판; 조경환; 양범석
- Salvianolic acid A; Scar; Dermal fibroblast; Macrophage
- Issue Date
- 대한창상학회지 (J Korean Wound Management Soc)
- VOL 5, NO 2, 79-87
- When Salvianolic acid A isolated from Danshen was applied for the full-excisional wound model in rabbit ear and
rat dorsal skin, it showed a biological activity to diminish the scar formation. This activity was correlated with the
suppression of macrophage activation. Salvianolic acid A treatment could suppress the stress-related signaling
pathways in J774A.1 mouse macrophage cells which was activated by LPS. This suppression was correlated with the
inhibition of inducible nitric oxide synthetase expression and focal adhesion kinase activation. In addition Salvianolic
acid treatment inhibited the proliferation and migration of rat dermal fibroblast with the reduction of alpha smooth
muscle actin expression. Taken together these data suggest that Salvianolic acid A can suppress the scar formation
by interfering with the activating signaling pathways of dermal fibroblast and macrophage in wound healing process.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.