Determination of Urinary Trimethylamine and Trimethylamine N-oxide by Liquid Chromatography-Tandem Mass Spectrometry Using Mixed-Mode Stationary Phases

Title
Determination of Urinary Trimethylamine and Trimethylamine N-oxide by Liquid Chromatography-Tandem Mass Spectrometry Using Mixed-Mode Stationary Phases
Authors
이상규김동현진창배유혜현
Keywords
TMA; LC-MS/MS; mixed-mode stationary phase; Trimethylamine; Trimethylamine N-oxide; Trimethylaminuria; Mixed-mode column
Issue Date
2010-02
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 31, NO 2, 483-486
Abstract
Trimethylamine (TMA), a volatile short-chain aliphatic amine, is derived from the diet either directly by the consumption of food high in TMA or by enterobacterial metabolism of dietary precursors such as choline, lecithin and possibly carnitine and other betaines.1,2 TMA is malodorous but normally oxidized to odorless trimethylamine N-oxide (TMANO) by flavin containing monooxygenase 3 (FMO3) (EC 1.14.13.8) in the liver and excreted from the body. However, when FMO3 is not working correctly or if not enough enzyme is produced, TMA from precursor compounds in food digestion is not properly broken down into TMANO. TMA then builds up and is excreted in the person's sweat, urine, breath, and other body secretions with a strong fishy odor or strong body odor. Trimethylaminuria or ‘fish odour syndrome’ (McKusick 602079) is known to be a metabolic syndrome caused by mutations of the FMO3 gene.
URI
http://pubs.kist.re.kr/handle/201004/45561
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE