Use of biospecific reactions for the design of high-sensitivity biosensors based on nanomechanical cantilever systems
- Use of biospecific reactions for the design of high-sensitivity biosensors based on nanomechanical cantilever systems
- Peter Gorelkin; G. Kiselev; D. Mukhin; 김태송; 김상경; 이상명; Igor Yaminsky
- cantilever; biosensor; deflection; DNA
- Issue Date
- Polymer science. Series A, Chemistry, physics / Russian Academy of Sciences
- VOL 52, NO 10, 1023-1033
- The study of nanomechanical cantilever systems is among the priority directions in the progres
sion of nanotechnologies. Principally new ways of designing biosensors based on nanocantilever transducers
are investigated, the effect of orientation of receptor immunoglobulin molecules in the sensor layer on the
formation of lateral strain during complementary binding is examined for the first time, and unique techniques for creation of selective receptor transducers based on cantilevers are developed. The unique data of
this study make it possible to state that, owing to the presence of 13-thiotridecane-1,1,2-triol molecules in
the probe DNA layer, the lateral strain tends to increase during hybridization of complementary molecules.
Theoretical predictions and experimental data are compared, and the effect of the formation of lateral strain
in polymer layers on the bending of the cantilever transducer is revealed. The nature of lateral strain arising
in films of biopolymers (proteins and DNA) during complementary binding (formation of the immune complex for protein molecules and hybridization for DNA) is ascertained.
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