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dc.contributor.authorXiang Lan Wu-
dc.contributor.author김종호-
dc.contributor.author구희범-
dc.contributor.author배상문-
dc.contributor.author신혜리-
dc.contributor.author김민상-
dc.contributor.author이병헌-
dc.contributor.author박랑운-
dc.contributor.author김인산-
dc.contributor.author최귀원-
dc.contributor.author권익찬-
dc.contributor.author김광명-
dc.contributor.author이두성-
dc.date.accessioned2015-12-03T00:59:53Z-
dc.date.available2015-12-03T00:59:53Z-
dc.date.issued201002-
dc.identifier.citationVOL 21, NO 2, 208-213-
dc.identifier.issn1043-1802-
dc.identifier.other33124-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/45586-
dc.description.abstractHerein, we prepared tumor-targeting peptide (AP peptide; CRKRLDRN) conjugated pH-responsive polymeric micelles (pH-PMs) in cancer therapy by active and pH-responsive tumor targeting delivery systems, simultaneously. The active tumor targeting and tumoral pH-responsive polymeric micelles were prepared by mixing AP peptide conjugated PEG-poly(D,L-lactic acid) block copolymer (AP-PEG-PLA) into the pH-responsive micelles of methyl ether poly(ethylene glycol) (MPEG)-poly( -amino ester) (PAE) block copolymer (MPEG-PAE). These mixed amphiphilic block copolymers were self-assembled to form stable AP peptide-conjugated and pH-responsive APPEG- PLA/MPEG-PAE micelles (AP-pH-PMs) with an average size of 150 nm. The AP-pH-PMs containing 10 wt % of AP-PEG-PLA showed a sharp pH-dependent micellization/demicellization transition at the tumoral acid pH. Also, they presented the pH-dependent drug release profile at the acidic pH of 6.4. The fluorescence dye, TRITC, encapsulated AP-pH-PMs (TRITC-AP-pH-PMs) presented the higher tumor-specific targeting ability in vitro cancer cell culture system and in vivo tumor-bearing mice, compared to control pH-responsive micelles of MPEG-PAE. For the cancer therapy, the anticancer drug, doxorubicin (DOX), was efficiently encapsulated into the AP-pH-PMs (DOX-AP-pH-PMs) with a higher loading efficiency. DOX-AP-pH-PMs efficiently deliver anticancer drugs in MDA-MB231 human breast tumor-bearing mice, resulted in excellent anticancer therapeutic efficacy, compared to free DOX and DOX encapsulated MEG-PAE micelles, indicating the excellent tumor targeting ability of AP-pH-PMs. Therefore, these tumor-targeting peptide-conjugated and pH-responsive polymeric micelles have great potential application in cancer therapy.-
dc.publisherBioconjugate chemistry-
dc.titleTumor-targeting peptide conjugated pH-responsive micelles as a potential drug carrier for cancer therapy-
dc.typeArticle-
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