Synthesis and Antiviral Evaluation of 1'-Branched-5'-Norcarbocyclic Adenosine Phosphonic Acid Analogues

Title
Synthesis and Antiviral Evaluation of 1'-Branched-5'-Norcarbocyclic Adenosine Phosphonic Acid Analogues
Authors
오창현유경호홍준희
Keywords
Antiviral agent; 1'-Branched nucleoside; 5'-Nornucleoside; Phosphonic acid nucleoside
Issue Date
2010-09
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 31, NO 9, 2473-2478
Abstract
Nucleosides play a major role in combating tumors and viruses, with modifications of natural nucleosides leading to novel antitumor and/or antiviral agents, including branched nucleosides such as DMDC,1 CNDAC,2 ECyd,3 4'α-C-ethenylthymidine, 4 and 4'α-C-ethynylthymidine5 as potent antiviral or antitumor agents. The 1'-substituted nucleosides such as angustmycin 16 and hydantocidin 27 are herbicidal and affect plant growth (Figure 1). However, only a few examples of 1'-substituted nucleosides of defined absolute stereochemistry are reported.8 The scarcity of examples of 1'-substituted nucleosides may be due to the synthetic difficulties for elaborating a necessary tertiary carbon center. We therefore developed efficient methodology to synthesize furanosyl or cyclopentane rings containing stereochemically defined tertiary carbons.
URI
http://pubs.kist.re.kr/handle/201004/45589
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
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