Performance Characteristic of the β-Human Chorionic Gonadotropin Assay on the Access 2 for its Use in Doping Control

Title
Performance Characteristic of the β-Human Chorionic Gonadotropin Assay on the Access 2 for its Use in Doping Control
Authors
강민정이혜임신상미유혜현권오승진창배정봉철
Keywords
β-hCG; Confirmation method; Access 2; Elecsys 2010; Method Evaluation; Doping control
Issue Date
2010-10
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 31, NO 10, 2889-2892
Abstract
The objective of this study was to validate performance characteristics of the Access 2 (Beckman coulter) system for hCG assays for use as a confirmation test for doping control. The Access 2 assay was linear up to 500 IU/L. The correlation coefficient was higher than 0.999, and the sensitivity of the linearity was 0.82. There were no false positive or false negative cases. LOD was 0.59 IU/L. The method was robust when performed by different people. Repeatability and reproducibility were below 7%. We compared reproducibility and recoveries of Access 2 and Elecsys 2010. Access 2 demonstrated higher reproducibility than Elecsys 2010. Recoveries (accuracy) of Access 2 were between 85 and 105%. Recoveries for Elecsys 2010 were between 91 and 104%.
URI
http://pubs.kist.re.kr/handle/201004/45590
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
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