The Excretion Study of 1,4,6-Androstatriene-3,17-dione(ATD) and its Metabolite in Human Urine

Title
The Excretion Study of 1,4,6-Androstatriene-3,17-dione(ATD) and its Metabolite in Human Urine
Authors
이지혜백선영정재연염태우팽기정김연제
Keywords
ATD; 대사체; 배설 양상; 1,4,6-Androstatriene-3,17-dione; Metabolite; Human urine; LC/ESI/MS; GC/MS
Issue Date
2010-12
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 31, NO 12, 3517-3518
Abstract
We have studied the excretion of ATD and its metabolite after oral dose in human urine, and evaluated the characterization method for ATD and its metabolite in human urine. We could detect ATD-M by LC/TOF-MS and the molecular weight was suspected 284 Da. After then, we applied the GC/TOF-MS for confirmation of ATD-M with trimethylsilylation. In the excretion profile study, the maximum level of ATD and ATD-M was at 14 hr and 16 hr, respectively. And the total amount to be excreted of ATD from 25.00 mg does was about 15.23 mg in urinary volume 2.6 L during 48 hr.
URI
http://pubs.kist.re.kr/handle/201004/45610
ISSN
0253-2964
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KIST Publication > Article
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