Thalamic ryanodine receptors are involved in controlling the tonic firing of thalamocortical neurons and inflammatory pain signal processing

Title
Thalamic ryanodine receptors are involved in controlling the tonic firing of thalamocortical neurons and inflammatory pain signal processing
Authors
정은지김찬기최지원선민정신희섭
Keywords
Thalamus; ryanodine receptor; inflammatory pain; calcium
Issue Date
2011-01
Publisher
Journal of neuroscience
Citation
VOL 31, NO 4, 1213-1218
Abstract
Ryanodine receptors (RyRs) are highly conductive intracellular Ca2+ release channels which are widely expressed in the CNS. They rapidly increase the intracellular Ca2+ concentrations in neuronal cells in response to Ca2+ influx through voltage-gated Ca2+ channels. A previous study reported that RyRs were expressed in thalamocortical (TC) neurons, but their physiological function has remained elusive. Here, we show that the activation of RyRs in TC neurons in mice decreases their tonic firing rate while blocking them induces the opposite response. Furthermore, activation of RyRs in ventroposteriomedial/ventroposteriolateral nuclei reduces the behavioral responses to inflammatory pain and blocking them increases the responses. This study highlights the importance of the intracellular Ca2+ release via RyRs in controlling the excitability of TC neurons and in inflammatory pain signal processing in the thalamus.
URI
http://pubs.kist.re.kr/handle/201004/45611
ISSN
0270-6474
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KIST Publication > Article
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