Thalamic ryanodine receptors are involved in controlling the tonic firing of thalamocortical neurons and inflammatory pain signal processing
- Thalamic ryanodine receptors are involved in controlling the tonic firing of thalamocortical neurons and inflammatory pain signal processing
- 정은지; 김찬기; 최지원; 선민정; 신희섭
- Thalamus; ryanodine receptor; inflammatory pain; calcium
- Issue Date
- Journal of neuroscience
- VOL 31, NO 4, 1213-1218
- Ryanodine receptors (RyRs) are highly conductive intracellular Ca2+ release channels which are widely expressed in the CNS. They
rapidly increase the intracellular Ca2+ concentrations in neuronal cells in response to Ca2+ influx through voltage-gated Ca2+ channels.
A previous study reported that RyRs were expressed in thalamocortical (TC) neurons, but their physiological function has remained
elusive. Here, we show that the activation of RyRs in TC neurons in mice decreases their tonic firing rate while blocking them induces the
opposite response. Furthermore, activation of RyRs in ventroposteriomedial/ventroposteriolateral nuclei reduces the behavioral responses
to inflammatory pain and blocking them increases the responses. This study highlights the importance of the intracellular Ca2+
release via RyRs in controlling the excitability of TC neurons and in inflammatory pain signal processing in the thalamus.
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