Glionitrin B, a cancer invasion inhibitory diketopiperazine produced by microbial coculture
- Glionitrin B, a cancer invasion inhibitory diketopiperazine produced by microbial coculture
- 박현봉; 김영주; 박진수; 양현옥; 이강노; 권학철
- New Compound; Microorganism; Co-Culture; Cancer Invasion; Glionitrin B
- Issue Date
- Journal of natural products
- VOL 74, NO 10, 2309-2312
- A new diketopiperazine, glionitrin B (1), was produced using a microbial coculture of the fungus Aspergillus fumigatus KMC-901 and the bacterium Sphingomonas sp. KMK-001 that were isolated from acidic coal mine drainage. The structure of 1 was determined to be (3S,10aS)-dithiomethylglionitrin A. This structure was determined by the analyses of extensive NMR data and the circular dichroism spectra of the natural product and a semisynthetic compound derived from glionitrin A. In contrast to glionitrin A (2), glionitrin B (1) is not cytotoxic against the human prostate cancer cell line DU145. However, compound 1 caused suppression of DU145 cell invasion, producing 46% inhibition at 60 μM.
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