Characterization of fucoxanthin-loaded microspheres composed of cetyl palmitatebased solid lipid core and fish gelatin-gum arabic coacervate shell
- Characterization of fucoxanthin-loaded microspheres composed of cetyl palmitatebased solid lipid core and fish gelatin-gum arabic coacervate shell
- Jie Quan; 김상민; 판철호; 정동화
- fucoxanthin; cetyl palmitate; microsphores; sustained release; storage stability
- Issue Date
- Food research international
- VOL 50, 31-37
- Fucoxanthin-loaded microspheres, composed of a cetyl palmitate (CP)–canola oil (CO) mixed solid lipid core
and a fish gelatin–gum arabic complex coacervate shell cross-linked by tannic acid, were developed and characterized
for efficient oral delivery of fucoxanthin. Two types of solid lipid-core microspheres (CP:CO=30:70
and 50:50) in both wet and freeze-dried forms were investigated in their morphology, size, moisture content,
and fucoxanthin encapsulation efficiency, in comparison with oil–core microspheres (CP:CO=0:100). The
melting and solidification of the cores were also analyzed by DSC. Compared to the oil–core microspheres,
the solid lipid-core microspheres, especially of CP:CO=50:50, exhibited greatly enhanced sustained fucoxanthin
release performance under a simulated gastrointestinal condition and much stronger fucoxanthin-stabilizing
capability when stored in the dark atmosphere of 0% or 51% relative humidity at 40 °C, although the encapsulation
efficiency was lowered from 85.34% to 74.81% with the increase of the CP fraction from 0% to 50%.
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