Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line

Title
Synthesis of New Pyrimidinylaminobenzene Derivatives and Their Antiproliferative Activities against Melanoma Cell Line
Authors
김희진오창현유경호
Keywords
Antiproliferative activity; Pyrimidinylaminobenzene; Diarylamide; Diarylurea; Melanoma
Issue Date
2013-08
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 34, NO 8, 2311-2316
Abstract
A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds 1a-c, k and 2b-d, f, g, j, l showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 2f possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with IC50 value in nanomolar scale.
URI
http://pubs.kist.re.kr/handle/201004/45831
ISSN
02532964
Appears in Collections:
KIST Publication > Article
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