Think Modular: A Simple Apoferritin-Based Platform for the Multifaceted Detection of Pancreatic Cancer
- Think Modular: A Simple Apoferritin-Based Platform for the Multifaceted Detection of Pancreatic Cancer
- 황민태; 이종욱; 이경은; 이관희
- apoferritin; modular; quantum dot; gold nanoparticle; pancreatic cancer
- Issue Date
- ACS Nano
- VOL 7, NO 9, 8167-8174
- The generation of nanosized probes often requires
time-intensive and application-specific optimization processes that
involve conjugating a nanoconstruct to a targeting moiety. Herein, we
genetically modify apoferritin and generate a universal interface
system composed of protein G and 6 His-tag. The resulting construct, conferred with modularity and high targeting efficiency, is applied toward two distinct
applications in the detection of a pancreatic cancer biomarker and used to demonstrate its potential in the facile exchange of nanoprobe components.
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