Think Modular: A Simple Apoferritin-Based Platform for the Multifaceted Detection of Pancreatic Cancer

Title
Think Modular: A Simple Apoferritin-Based Platform for the Multifaceted Detection of Pancreatic Cancer
Authors
황민태이종욱이경은이관희
Keywords
apoferritin; modular; quantum dot; gold nanoparticle; pancreatic cancer
Issue Date
2013-09
Publisher
ACS Nano
Citation
VOL 7, NO 9, 8167-8174
Abstract
The generation of nanosized probes often requires time-intensive and application-specific optimization processes that involve conjugating a nanoconstruct to a targeting moiety. Herein, we genetically modify apoferritin and generate a universal interface system composed of protein G and 6 His-tag. The resulting construct, conferred with modularity and high targeting efficiency, is applied toward two distinct applications in the detection of a pancreatic cancer biomarker and used to demonstrate its potential in the facile exchange of nanoprobe components.
URI
http://pubs.kist.re.kr/handle/201004/45905
ISSN
19360851
Appears in Collections:
KIST Publication > Article
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