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dc.contributor.author조인하-
dc.contributor.author이민정-
dc.contributor.author김대환-
dc.contributor.author김보라-
dc.contributor.author배점일-
dc.contributor.author최규용-
dc.contributor.author김선명-
dc.contributor.author허은현-
dc.contributor.author이근호-
dc.contributor.author김종현-
dc.contributor.author송우근-
dc.date.accessioned2015-12-03T01:01:05Z-
dc.date.available2015-12-03T01:01:05Z-
dc.date.issued201311-
dc.identifier.citationVOL 70, NO 22, 4369-4383-
dc.identifier.issn1420682X-
dc.identifier.other40238-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/45909-
dc.description.abstractActin plays a fundamental role in the regulation of spine morphology (both shrinkage and enlargement) upon synaptic activation. In particular, actin depolymerization is crucial for the spine shrinkage in NMDAR-mediated synaptic depression. Here, we define the role of SPIN90 phosphorylation/dephosphorylation in regulating actin depolymerization via modulation of cofilin activity. When neurons were treated with NMDA, SPIN90 was dephosphorylated by STEP61 (striatalenriched protein tyrosine phosphatase) and translocated from the spines to the dendritic shafts. In addition, phosphorylated SPIN90 bound cofilin and then inhibited cofilin activity, suggesting that SPIN90 dephosphorylation is a prerequisite step for releasing cofilin so that cofilin can adequately sever actin filaments into monomeric form. We found that SPIN90 YE, a phosphomimetic mutant, remained in the spines after NMDAR activation where it bound cofilin, thereby effectively preventing actin depolymerization. This led to inhibition of the activity-dependent redistribution of cortactin and drebrin A, as well as of the morphological changes in the spines that underlie synaptic plasticity. These findings indicate that NMDAinduced SPIN90 dephosphorylation and translocation initiates cofilin-mediated actin dynamics and spine shrinkage within dendritic spines, thereby modulating synaptic activity.-
dc.publisherCellular and molecular life sciences : CMLS-
dc.subjectDendritic spines-
dc.subjectSpine shrinkage-
dc.subjectLong-term depression-
dc.subjectActin depolymerization-
dc.titleSPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons-
dc.typeArticle-
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