Phospholipase C-β1 and schizophrenia-related behaviors
- Phospholipase C-β1 and schizophrenia-related behaviors
- phospholipase C-beta1; schizophrenia; behavior; signalling
- Issue Date
- advances in biological regulation
- VOL 53, NO 3, 242-248
- Abnormal expression patterns of phospholipase C-b1(PLC-b1) in
specific brain areas of patients with schizophrenia, and its high
genetic linkage to the disorder implicated a pathogenetical
involvement of PLC-b1 signaling system. The schizophreniarelated
behavioral phenotypes displayed in the mutant mice
lacking PLC-b1 (PLC-b1 KO) suggested that PLCb1-linked signaling
pathways may be involved in the neural system whose function is
disrupted in the pathogenesis of schizophrenia. In the brain, PLCb1
is known to be linked to muscarinic acetylcholine receptors,
metabotropic glutamatergic, serotonergic, and oxytocinergic systems.
The objective of this review is to provide an overview of the
current knowledge regarding these schizophrenia-related behaviors
and discuss the probable ways in which PLC-b1signalling can
be involved in the neural mechanisms for each behavior, which
may help suggest future directions for research in this area.
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