Phospholipase C-β1 and schizophrenia-related behaviors

Title
Phospholipase C-β1 and schizophrenia-related behaviors
Authors
고혜영
Keywords
phospholipase C-beta1; schizophrenia; behavior; signalling
Issue Date
2013-09
Publisher
advances in biological regulation
Citation
VOL 53, NO 3, 242-248
Abstract
Abnormal expression patterns of phospholipase C-b1(PLC-b1) in specific brain areas of patients with schizophrenia, and its high genetic linkage to the disorder implicated a pathogenetical involvement of PLC-b1 signaling system. The schizophreniarelated behavioral phenotypes displayed in the mutant mice lacking PLC-b1 (PLC-b1 KO) suggested that PLCb1-linked signaling pathways may be involved in the neural system whose function is disrupted in the pathogenesis of schizophrenia. In the brain, PLCb1 is known to be linked to muscarinic acetylcholine receptors, metabotropic glutamatergic, serotonergic, and oxytocinergic systems. The objective of this review is to provide an overview of the current knowledge regarding these schizophrenia-related behaviors and discuss the probable ways in which PLC-b1signalling can be involved in the neural mechanisms for each behavior, which may help suggest future directions for research in this area.
URI
http://pubs.kist.re.kr/handle/201004/45911
ISSN
22124926
Appears in Collections:
KIST Publication > Article
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