Electrophysiological Characteristic of Optogenetic Stimulation in Parkinsonian Mice

Title
Electrophysiological Characteristic of Optogenetic Stimulation in Parkinsonian Mice
Authors
송강일박성희추준욱서준교최귀원황도식윤인찬
Keywords
Optogenetics; Parkinson's disease; Deep brain stimulation; Optogenetic Stimulation
Issue Date
2013-08
Publisher
Asian Pacific Conference on Biomechanics
Abstract
Deep brain stimulation (DBS) of subthalamic nucleus (STN) is recognized as a therapeutic option for intractable neurological disorders such as parkinson’s disease. Even though the DBS has shown therapeutic effects, it is unclear which circuit elements are responsible for the therapeutic effects. In principle, DBS can directly activate a wide range of neural elements in STN. The aim of this study is to find therapeutic effects within the subthalamic nucleus by selective stimulation of afferent axons projecting to this region using the optogenetics. The spontaneous activity was recorded from unilateral 6-hydroxydopamine lesioned transgenic mice (Thy1::ChR2) model of parkinson’s disease in STN. The optical stimulation was modulated with 473 nm blue laser; high-frequency stimulation (HFS, 130 Hz) and low-frequency stimulation (LFS, 20 Hz) with microelectrode recording. While the results show that the STN spiking across all frequency band are reduced during HFS, burst firing with increasing beta frequency (10~20 Hz) firing still remained during LFS. From the results of this study, the effects of STN-DBS in basal ganglia circuit elements (STN, M1, GPi, GPe) will be studied to understand the mechanism of DBS with functional magnetic resonance imaging (fMRI) in the future.
URI
http://pubs.kist.re.kr/handle/201004/45923
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KIST Publication > Conference Paper
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