Electrophysiological Characteristic of Optogenetic Stimulation in Parkinsonian Mice
- Electrophysiological Characteristic of Optogenetic Stimulation in Parkinsonian Mice
- 송강일; 박성희; 추준욱; 서준교; 최귀원; 황도식; 윤인찬
- Optogenetics; Parkinson's disease; Deep brain stimulation; Optogenetic Stimulation
- Issue Date
- Asian Pacific
Conference on Biomechanics
- Deep brain stimulation (DBS) of subthalamic nucleus (STN) is recognized as a therapeutic option for intractable
neurological disorders such as parkinson’s disease. Even though the DBS has shown therapeutic effects, it is
unclear which circuit elements are responsible for the therapeutic effects. In principle, DBS can directly activate
a wide range of neural elements in STN. The aim of this study is to find therapeutic effects within the
subthalamic nucleus by selective stimulation of afferent axons projecting to this region using the optogenetics.
The spontaneous activity was recorded from unilateral 6-hydroxydopamine lesioned transgenic mice
(Thy1::ChR2) model of parkinson’s disease in STN. The optical stimulation was modulated with 473 nm blue
laser; high-frequency stimulation (HFS, 130 Hz) and low-frequency stimulation (LFS, 20 Hz) with
microelectrode recording. While the results show that the STN spiking across all frequency band are reduced
during HFS, burst firing with increasing beta frequency (10~20 Hz) firing still remained during LFS. From the
results of this study, the effects of STN-DBS in basal ganglia circuit elements (STN, M1, GPi, GPe) will be
studied to understand the mechanism of DBS with functional magnetic resonance imaging (fMRI) in the future.
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