Tripartin, a Histone Demethylase Inhibitor from a Bacterium Associated with a Dung Beetle Larva

Title
Tripartin, a Histone Demethylase Inhibitor from a Bacterium Associated with a Dung Beetle Larva
Authors
김성환권소희박선희이재균방해손남상집권학철신종헌오동찬
Keywords
Dung Beetle Larva; ORTEP diagram; bacterial symbionts
Issue Date
2013-04
Publisher
Organic letters
Citation
VOL 15, NO 8, 1834-1837
Abstract
Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.
URI
http://pubs.kist.re.kr/handle/201004/46062
ISSN
15237060
Appears in Collections:
KIST Publication > Article
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