Next-generation transgenic mice for optogenetic analysis of neural circuits

Title
Next-generation transgenic mice for optogenetic analysis of neural circuits
Authors
Brent Asrican조지어거스틴Ken BerglundSusu ChenNicholas ChowKarl DeisserothGuoping FengBernd GlossRiichiro HiraCarolin HoffmannHaruo KasaiMalvika KataryaJinsook KimJohn KudoloLiming LeeShun-Qiang LoJames MancusoMasanori Matsuzak류이치 나카지마Li QuiGregory TanYanxia TangJonathan T. TingSachiko Tsuda레이웬Xuying ZhangShengli Zhao
Keywords
optogenetics; channelrhodopsin; photostimulation; photoinhibition; mouse genetics; Cerebellum; Cortex; Hippocampus; Pons
Issue Date
2013-09
Publisher
FRONTIERS IN NEURAL CIRCUITS
Citation
VOL 2013, NO 9, PDF
Abstract
Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.
URI
http://pubs.kist.re.kr/handle/201004/46155
ISSN
16625110
Appears in Collections:
KIST Publication > Article
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