Comparison of metabolic ratios of urinary estrogens between benign and malignant thyroid tumors in postmenopausal women

Title
Comparison of metabolic ratios of urinary estrogens between benign and malignant thyroid tumors in postmenopausal women
Authors
문주연이은직정웅윤문명희정봉철최만호
Keywords
estrogen; menopause; thyroid cancer; Estrogens; Postmenopause; 16α-hydroxylation; 17β-hydroxysteroid dehydrogenase
Issue Date
2013-10
Publisher
BMC clinical pathology. [electronic resource]
Citation
VOL 13, 25-1-25-8
Abstract
Background Estrogen metabolism may be associated with the pathophysiological development of papillary thyroid carcinoma (PTC). Methods To evaluate the differential estrogen metabolism between benign and malignant PTCs, estrogen profiling by gas chromatography&#8211;mass spectrometry was applied to urine samples from postmenopausal patients with 9 benign tumors and 18 malignant stage I and III/IV PTCs. Results The urinary concentration of 2-methoxyestradiol was significantly lower in the stage I malignant patients (3.5-fold; P&#8201;<&#8201;0.025) than in the benign group. The metabolic ratios of 16α-OH-estrone/estrone and estriol/estradiol, which are responsible for 16α-hydroxylase activity, were increased more than 2.5-fold in the advanced-stage malignant PTC (P&#8201;<&#8201;0.02 each). The more than 6.2-fold decrease in the urinary 2-/16α-hydroxylase ratio in stage III/IV malignant PTC was consistent with the ratio in postmenopausal patients with endocrine gland cancers. In addition, reductive 17β-hydroxysteroid dehydrogenase (17β-HSD; estradiol/estrone or estriol/16α-OH-estrone) was present at significantly higher levels in subjects with stage III/IV malignant PTCs than in benign subjects (>3.5-fold difference; P&#8201;<&#8201;0.002). In particular, the estriol/16α-OH-estrone ratio differentiated between the benign and early-stage malignant patients (P&#8201;<&#8201;0.01). Conclusions Increased 16α-hydroxylation and/or a decreased 2-/16α-ratio, as well increased reductive 17β-HSD, with regard to estrogen metabolism could provide potential biomarkers. The devised profiles could be useful for differentiating malignant thyroid carcinomas from benign adenomas in postmenopausal women.
URI
http://pubs.kist.re.kr/handle/201004/46159
ISSN
14726890
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