Distant metastases and survival prediction in head and neck squamous cell carcinoma

Title
Distant metastases and survival prediction in head and neck squamous cell carcinoma
Authors
이동환김민주노종렬김성배최승호남순열김상윤
Keywords
distant metastasis; head and neck; squamous cell carcinoma; risk factors
Issue Date
2012-11
Publisher
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
Citation
VOL 147, NO 5, 870-875
Abstract
Subjects and Methods. Four hundred four eligible patients were involved who were treated with a minimum 2-year follow-up from January 2005 through August 2009. Confirmation of DM was performed by histopathology or follow-up imaging. Univariate and multivariate analyses were used for factors predictive of DM. The survival of patients was calculated by the Kaplan-Meier method. Results. Thirty-six of the 404 eligible patients (8.9%) developed DM, most frequently in the lungs (80.6%). Univariate analyses revealed that T and N classifications, lymphovascular invasion and perineural invasion of the primary tumor, and locoregional recurrences were each significantly associated with the development of DM (P < .05). Multivariate analyses showed that T and N classifications and locoregional recurrences were independent predictors of DM (P < .05). The overall 1- and 2-year survival rates of the 36 patients with DMs were 40.6% and 13.5%, respectively. Metastases to more than 1 organ negatively affected patient survival (P < .001). Conclusion. Patients with advanced tumors, nodal involvement, or locoregional recurrences may require more frequent surveillance for the development of DMs.
URI
http://pubs.kist.re.kr/handle/201004/46236
ISSN
01945998
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KIST Publication > Article
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