Distant metastases and survival prediction in head and neck squamous cell carcinoma
- Distant metastases and survival prediction in head and neck squamous cell carcinoma
- 이동환; 김민주; 노종렬; 김성배; 최승호; 남순열; 김상윤
- distant metastasis; head and neck; squamous cell carcinoma; risk factors
- Issue Date
- OTOLARYNGOLOGY-HEAD AND NECK SURGERY
- VOL 147, NO 5, 870-875
- Subjects and Methods. Four hundred four eligible patients were
involved who were treated with a minimum 2-year follow-up
from January 2005 through August 2009. Confirmation of DM
was performed by histopathology or follow-up imaging.
Univariate and multivariate analyses were used for factors predictive
of DM. The survival of patients was calculated by the
Results. Thirty-six of the 404 eligible patients (8.9%) developed
DM, most frequently in the lungs (80.6%). Univariate analyses
revealed that T and N classifications, lymphovascular invasion
and perineural invasion of the primary tumor, and locoregional
recurrences were each significantly associated with the development
of DM (P < .05). Multivariate analyses showed that T
and N classifications and locoregional recurrences were independent
predictors of DM (P < .05). The overall 1- and 2-year
survival rates of the 36 patients with DMs were 40.6% and
13.5%, respectively. Metastases to more than 1 organ negatively
affected patient survival (P < .001).
Conclusion. Patients with advanced tumors, nodal involvement,
or locoregional recurrences may require more frequent
surveillance for the development of DMs.
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